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Natural Sciences

– Marcin Berndt

If the joint project of scientists from Warsaw and Toro succeeds, implantologists may be out of work within a dozen years or so. Researchers want to implant a third set of teeth based on stem cells found in the gums.

SteamScaf is a project funded under the Research University Excellence Initiative of the Warsaw University of Technology. Its leader is Dr. Love. M. Agnieszka Gadomska-Gajadhur from the Faculty of Chemistry, Warsaw University of Technology. DC researchers are designing polymers, spatio-structures, and scaffolds that will be implanted with stem cells in the future. A distinctive feature of these cells is that they have the ability to transform into other types of cells. It is they who generate all the cell lines that make up the body. Dr. Love. Dorota Bukovska, A.; umk and dr love. Paweł Antosik, A.; NCU of the Institute of Veterinary Medicine at Nicolas Copernicus University is responsible for tests on animal models, prof. Doctor Hub. Bartosz Kempisty conducts cellular research.

Today’s science depends on the cooperation of various branches of knowledge – the professor emphasizes. Bukovska. – The time of Maria Curie-Skłodowska – The era of solitary white sails is long gone.

Work on the third set of teeth began with the isolation of animal material, and the selection and collection of appropriate tissues: the palate, gums and dental pulp, from which the appropriate cells would be selected for further research.

a.  Doctor Hub.  Bartosz Kempty sitting in front of the building of the Faculty of Biological and Veterinary Sciences at Nicolas Copernicus University
a. Doctor Hub. Bartosh Kempty
Photography by Andrzej Romański

Scientists from different stem cells create a homogeneous group, that is, a homogeneous group. Then they have to give it a new character, a new purpose. After the changes, a particular cell will no longer be responsible for the tasks that were previously assigned to it, for example in the gums. – On the basis of differentiated cells, we can create foundations for future tissues – explains Professor D. Kempisty. – When we get polymer scaffolds from Dr. Jadomska-Jajador, we will place cells on them and investigate to what extent they can multiply on biocompatible and biodegradable polymers and create a spatial structure, similar to tissues. When we have a structure that imitates tissue in vivoIn the body, we will focus on whether and where it can be implanted.

There is still a long way to go to get a set of third teeth in a human, but it is possible to get by. In Japan, at the beginning of this century, it was possible to implant artificial teeth in mice. He had normal morphology, physiology, blood supply and innervation. Similar projects are being implemented all over the world.

King’s College London, with which we cooperate, also sought to create artificial human teeth – recalls the professor. Kempisty

The researchers explained that they should focus on preparing the cells in the laboratory, biomaterials compatible with cells and germs, i.e. tissue origins. Only later will they be able to think about creating a real tooth structure. – Currently, the biological and biotechnological part of the team obtains tissues, differentiates, selects and differentiates cells – the professor explains. Kempisty. – During differentiation we check for cells that divide into chondrocytes, osteoblasts or nerve-like cells. Because these three matter to us. After completing the SteamScaf project, the scaffolds should be implanted with cells, and tissue oocytes. If the experiments are successful, we will proceed to work on live animals, because at the moment we are working on post-mortem material, for which we do not need approval from the Bioethics Committee.

a.  Doctor Hub.  Bartosh Kempty
a. Doctor Hub. Bartosh Kempty
Photography by Andrzej Romański

Molecular-cellular research is carried out at the Interdisciplinary Center for Modern Technologies of the Nicolas Copernicus University by young veterinarians. Scientists from Toruń University provide access to animal materials. Internally, a. Dorota Bukovska and Prof. Pawe Antosik is responsible for animal evaluation and selection, collection of animal materials and later their potential use in animals, initially in preclinical research. Scientists are working on a domestic pig model. – We associate research on animals with rats and mice, and we often consider them to be more interesting than pigs – says the Professor. Kempisty. But the pig’s genome is 95 percent close. coincides with the human genome. Just how important these animals are to the future of organ transplantation is demonstrated by the successful transplantation of a pig’s heart in humans. This was done on January 11, 2022 by the professor’s team. Bartley Griffiths, director of the Heart Transplant Program at the University of Maryland Medical Center (unfortunately, two months after transplantation, the patient died – editor). Previously, humans had undergone a pig kidney transplant.

Research conducted on the same animal model, using other tissues and organs such as the heart, umbilical cord blood, Wharton’s jelly and stem cells from other human and animal organs, showed that they can be distinguished and obtained tissue eggs – adds the professor. Kempisty. – Collaboration in research using stem cells, which we have been doing in collaboration with the Institute of Veterinary Medicine for several decades, is exemplary. Toru’s veterinary medicine is not limited to research on animals, but it also bows to and praises human medicine, both regenerative and restorative.

Scientists assume that work on the third set of human teeth will take at least a dozen years or so.

Research is the first step in the laboratoryBut – even if their results are impressive, the real test, the course of which is unpredictable, is the use of solutions developed on a living organism. If you are looking in vivo Fail, you have to start over.

Could any hope of accelerating business be the use of cutting-edge technology for 3D bioprinting? a. Kempisty notes that it works well with individual reservoirs, but it won’t work with a complex structure like human teeth.

Researchers stress that in biology, medicine, veterinary medicine, and the life sciences, breakthroughs sometimes depend on chance. They remember that Alexander Fleming discovered penicillin by omission and neglect. – If everything goes according to plan, we want to create tissue buds in the next few years – says the professor. Kempisty. – The work on artificial teeth will certainly be longer and will require support not only from the Warsaw University of Technology, but also from laboratories, institutes, universities and other institutions that deal with both tissue bioengineering and biomechanics. It is also indispensable to help the business that you will help fund. We currently rely on funds from the National Science Center and the National Research and Development Center, and will continue to apply for them.

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